I am having a problem with my big dog, Quinn, and want to know if anyone else has done any research on this. I live in CT - the state that gave you lyme disease! When I got my Quinn, I gave him the lyme vaccine - he tolerated it fine, and this is his third year to receive it. Shortly after the vaccine, he got up one morning with a terrible limp in his left rear foot, so much so, that he held it up and hobbled on it. We brought him in, the vet had just ran a lyme titer on him, and it had showed negative, before he had the vaccine. He then had another titer, and that came up negative. Because we had brought in my other dog, and hers came up positive for ehrliociosis, we thought maybe the tests were switched and ran another test on Quinn, still negative. She felt around, nothing broken, etc., but still limping. We gave him rimadyl, and that seemed to help. It seems to come and go, the lameness. He won't be limp in the a.m., but at the end of the day, when he gets up from laying down to go into his bed, he is really limping. We have been going to a chiropracter, and he has had some acupuncture. For about a week he was fine, and then this week it came back and he was really limping. The chiropracter vet thought she felt tenderness in his spine, so she said try a course of antibiotics. I am kind of at a loss right now. I guess I will try the course of antibiotics, but they are pretty strong, and probably will effect his tummy. Any thoughts from fellow doodle owners? Thanks!