Taking Seamus to the vet... Update test results

We are bringing Seamus to the vet this afternoon. I'm the type of person who likes to know as much as I can before talking to a vet (or any doctor for that matter) so I'm looking for some ideas. We found a swollen lymph node (pretty sure it's what it is) on the back of Seamus' back leg. He is 2 years old, has thus far been a healthy big guy. He is neutered, well-exercised... From my research online it seems like it can be any number of things. I don't want to even think about the worst case scenario...but of course that's in the back of my mind. I've also read that a swollen lymph node can be a sign of lyme disease. He does get the lyme shot, but who knows what that really does. We also did just return from a vacation in Tennessee, where we did do some hiking with the pups. He has been getting Frontline as well (although I wanted to stop giving him that in the future.) Other than some limping when running on that leg and acting kind of babyish the past day, he is not showing any other symptoms. He is still eating, playing, pooping, etc. Not overly tired from what I can tell. The node (or growth or who knows what it is..) is pretty large...you can't see it but can easily feel it. Has anyone experienced anything like this with a younger dog?? My husband thought maybe a muscle pull or something that would swell his leg a little, but when I googled canine lymph nodes I found a diagram and there is a node in the spot where I feel a bump. Can anyone also think of any questions I should be asking my vet as well? Like I said before, I like to be thorough with my vet because sometimes he doesn't offer as much information as he should (in my opinion at least lol). I will keep everyone updated once we get home later this afternoon. Thanks so much everyone.

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